期刊文献+

NKCC1 and NKCC2:The pathogenetic role of cation-chloride cotransporters in hypertension 被引量:1

原文传递
导出
摘要 This review summarizes the data on the functional significance of ubiquitous(NKCC1)and renal-specific(NKCC2)isoforms of electroneutral sodium,potassium and chloride cotransporters.These carriers contribute to the pathogenesis of hypertension via regulation of intracellular chloride concentration in vascular smooth muscle and neuronal cells and via sensing chloride concentration in the renal tubular fluid,respectively.Both NKCC1 and NKCC2 are inhibited by furosemide and other high-ceiling diuretics widely used for attenuation of extracellular fluid volume.However,the chronic usage of these compounds for the treatment of hypertension and other volume-expanded disorders may have diverse side-effects due to suppression of myogenic response in microcirculatory beds.
出处 《Genes & Diseases》 SCIE 2015年第2期186-196,共11页 基因与疾病(英文)
基金 This work was supported by grants from the Canadian Institutes for Health Research(MOP-81392)(S.N.O.) Russian Foundation for Fundamental Research##14-04-31705(S.V.K.),15-04-00101(S.N.O.) the Russian Scientific Foundation#14-15-00006(S.N.O.) the USA National Institutes of Health Award R01-GM85058(N.O.D.).
  • 相关文献

同被引文献4

引证文献1

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部