摘要
The 2019 Nobel Prize in Physiology or Medicine was awarded to three physician scientists,Drs.William G.Kaelin,Jr.,Peter Ratcliffe and Gregg Semenza,for their groundbreaking work revealing how cells sense and adapt to oxygen availability.Here,we summarize the history of their discoveries.
基金
We are eternally grateful for the invaluable guidance provided by Dr.William Kaelin of the Dana-Farber Cancer Institute of Harvard Medical School during our memorable postdoctoral training.We also thank the Science Bulletin in China for granting permission for the reprint.33 We apologize to the numerous investigators whose important relevant publications cannot be cited due to space constraints.The research conducted in the authors’laboratories was supported in part by grants from the American Cancer Society Research Scholar Award(to Q.Z),the National Institutes of Health(R01CA211732 to Q.Z.and R01CA237586 and P50CA121974(to Q.Y.))
the Cancer Prevention&Research Institute of Texas(to Q.Z),and the VHLA award(to H.Y.).The funding sources were not involved in the study design,in the collection,analysis and interpretation of data,in the writing of the report,or in the decision to submit the paper for publication.
