普萘洛尔与甲巯咪唑丙硫氧嘧啶连用在甲亢患者中临床疗效及安全性分析

Analysis of Clinical Efficacy and Safety of Propranolol Combined with Methimazole and Propylthiouracil in Patients with Hyperthyroidism

目的:探讨普萘洛尔分别联合甲巯咪唑、丙硫氧嘧啶对甲状腺功能亢进症的临床疗效。方法:选取180例甲状腺功能亢进症患者作为研究对象,研究时间为2015年10月至2017年10月,采用简单数据表法简单随机分为对照组(给予普萘洛尔与丙硫氧嘧啶治疗)与观察组(给予普萘洛尔联合甲巯咪唑治疗),各90例,且对两组患者的总有效率、游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、促甲状腺激素(TSH)、骨钙素(OCN)、Ⅰ型胶原羧基端肽β特殊序列(β-CTX)及不良反应发生率进行观察及评估。结果:观察组总有效率高于对照组(χ^2=12.291,P<0.05)。治疗3个月后观察组的FT3、FT4、OCN、β-CTX低于对照组,而TSH高于对照组(P均<0.05);且观察组FT3、FT4、TSH、OCN、β-CTX的治疗前后差值大于对照组(P<0.05)。观察组不良反应发生率低于对照组(χ^2=5.178,P<0.05)。结论:普萘洛尔联合甲巯咪唑在甲状腺功能亢进症患者治疗中具有较好的疗效,既能调节甲状腺激素水平,又能保证安全性。

Objective:To investigate the clinical efficacy of propranolol combined with methimazole and propylthiouracil on hyperthyroidism.Methods:180 patients with hyperthyroidism were selected as the research objects.The study period was from October 2015 to October 2017.According to a Simple Random Method Using Simple Data,They were divided into a control group(treated with propranolol and propylthiouracil)and observation Sheet Group(given propranolol combined with methimazole treatment),90 cases in each group,and the total effective rate,free triiodothyronine(FT3),free thyroxine(FT4),and thyroid stimulating hormone(TSH),osteocalcin(OCN),type I collagen carboxy-terminal peptideβ-special sequence(β-CTX)and the incidence of adverse reactions were observed and evaluated.Results:The total effective rate of the observation group was higher than that of the control group(χ^2=12.291,P<0.05).After 3 months of treatment,the observation group's FT3,FT4,OCN,β-CTX were lower than the control group,while TSH was higher than the control group(P<0.05);and the observation group FT3,FT4,TSH,OCN,β-CTX The difference before and after treatment was greater than that of the control group(P<0.05).The incidence of adverse reactions in the observation group was lower than that in the control group(χ^2=5.178,P<0.05).Conclusion:Propranolol combined with methimazole has a good effect in the treatment of patients with hyperthyroidism,which can regulate the level of thyroid hormones and ensure safety.