两种药物治疗小儿急性呼吸道感染对患儿血清CRP PA和IL-6水平的影响比较

Comparison on Effects of Two Drugs in Treatment of Children with Acute Respiratory Infection on Serum CRP PA and IL-6 Levels

目的:比较头孢克肟、头孢克洛治疗小儿急性呼吸道感染对患儿血清C反应蛋白(CRP)、前白蛋白(PA)和白细胞介素-6(IL-6)水平的影响。方法:选取2018年7月至2019年6月在我院治疗小儿急性呼吸道感染患儿78例为研究对象,采用随机数字表法将其分为观察组和对照组,39例/组,对照组给予头孢克肟干混悬剂治疗,观察组给予克洛己新干混悬剂治疗。比较两组治疗疗效及临床症状消失时间;比较两组治疗前后血清CRP、PA、降钙素原(PCT)水平及IL-6、白细胞介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)水平;统计两组患儿治疗期间胃肠道反应、脓栓、发炎等不良反应发生情况。结果:观察组治疗总有效率为94.87%,高于对照组79.49%(P<0.05);观察组临床症状消失时间短于对照组(P<0.05);观察组治疗前后血清CRP、PA、PCT水平及IL-6、TNF-α水平差值大于对照组(P<0.05)。结论:相比于头孢克肟干混悬剂,克洛己新干混悬剂治疗小儿急性呼吸道感染有效率较高,可缩短临床症状消失时间,减轻患儿炎症反应。

Objective:To compare the effects of cefixime and cefaclor in treatment of children with acute respiratory infection(ARI)on levels of serum C-reactive protein(CRP),prealbumin(PA)and interleukin-6(IL-6).Methods:During the period from July 2018 to June 2019,78 ARI children who were treated in the hospital were enrolled as research subjects.They were divided into control group and observation group with random number table,39 cases in each group.The observation group and control group were treated with cefaclor and bromhexine hydrochloride for suspension and cefixime for suspension,respectively.The curative effect and disappearance time of clinical symptoms,levels of serum CRP,PA,procalcitonin(PCT),IL-6,interleukin-8(IL-8)and tumor necrosis factor-α(TNF-α)before and after treatment were compared.The gastrointestinal reactions,adverse reactions such as pus embolus and inflammation during treatment in both groups were statistically analyzed.Results:The total response rate of treatment in observation group was higher than that in control group(94.87%vs 79.49%)(P<0.05),while disappearance time of clinical symptoms was shorter than that in control group(P<0.05).The difference of serum CRP,PA,PCT level and IL-6、TNF-αlevel in the observation group before and after treatment was greater than that in the control group(P<0.05).Conclusion:Compared with cefixime for Suspension,Cefaclor and Bromhexine Hydrochloride for Suspension is more effective in treatment of ARI children,which can shorten disappearance time of clinical symptoms,and relieve inflammation response.