口腔种植修复术患者种植体预后和炎性相关指标关系研究

Study on the Relationship between the Prognosis of Dental Implants and Related Indicators of Inflammation

目的探析口腔种植修复术患者种植体预后和炎性相关指标关系。方法方便选取该院2016年1月—2019年12月期间行口腔种植修复术的260例患者为实验组,同时选取同期260名健康体检者为对照组,对比分析两组炎性相关指标水平及其与种植体预后的关系。结果实验组术后1周、1个月血清C反应蛋白(CRP)、肿瘤坏死因子α(TNF-α)、白细胞介素-1(IL-1)、白细胞介素-6(IL-6)水平分别为(2.68±0.46)mg/L、(1.50±0.39)mg/L、(5.50±1.46)μg/L、(4.30±1.22)μg/L、(0.30±0.07)μg/L、(0.25±0.05)μg/L、(0.22±0.05)μg/L、(0.16±0.03)μg/L,均明显高于对照组,差异有统计学意义(t=8.260、8.640、8.460、9.010、8.240、8.190、8.550、9.310,P<0.05)。种植体结合良好者CRP、TNF-α、IL-1、IL-6水平分别为(1.45±0.41)mg/L、(4.23±1.13)μg/L、(0.24±0.06)μg/L、(0.15±0.04)μg/L,均明显低于种植体结合不良者,差异有统计学意义(P<0.05)。结论在口腔种植修复术治疗中,炎性相关指标水平明显升高,且与种植体预后密切相关,临床应予以高度重视。

Objective To explore the relationship between the prognosis of dental implants and related inflammatory indexes in patients undergoing dental implant restoration.Methods 260 patients who underwent oral implant restoration in the hospital from January 2016 to December 2019 were conveniently selected as the experimental group,and 260 healthy physical examination patients during the same period were selected as the control group.The two groups were compared and analyzed the levels of inflammation-related indicators relationship with implant prognosis.Results Serum C-reactive protein(CRP),tumor necrosis factorα(TNF-α),interleukin-1(IL-1),and interleukin-6(IL-6)in the experimental group 1 week and 1 month after operation were(2.68±0.46)mg/L,(1.50±0.39)mg/L,(5.50±1.46)μg/L,(4.30±1.22)μg/L,(0.30±0.07)μg/L,(0.25±0.05)μg/L,(0.22±0.05)μg/L,(0.16±0.03)μg/L,all were significantly higher than the control group,and the difference was statistically significant(t=8.260,8.640,8.460,9.010,8.240,8.190,8.550,9.310,P<0.05).The levels of CRP,TNF-α,IL-1,and IL-6 in those with good implant combination were(1.45±0.41)mg/L,(4.23±1.13)μg/L,(0.24±0.06)μg/L,(0.15±0.04)μg/L,which were significantly lower than those with poor implant integration,and the difference was statistically significant(P<0.05).Conclusion In the treatment of oral implant restoration,the level of inflammation-related indicators is significantly increased,and it is closely related to the prognosis of implants,and clinical attention should be paid to it.