某院24例亚胺培南/西司他丁不良反应报告分析

Analysis of 24 adverse reactions of imipenem-cilastatin in a hospital

目的分析某院近5年亚胺培南/西司他丁发生的不良反应(ADRS),为临床合理用药提供参考。方法回顾性调查某院2015年1月~2020年5月上报的亚胺培南/西司他丁所致ADRS 24例并进行统计分析。结果亚胺培南/西司他丁常见ADRS为谵语、躁动不安、幻觉、胃肠道反应,老年患者更易发生,男性多于女性。结论中枢神经系统副作用为亚胺培南/西司他丁最常见的ADRS,临床应用应高度重视,提高临床用药安全意识。

Objective To analyze the adverse drug reactions(ADRS)caused by Imipenem-cilastatin in recently 5years in our hospital and provide reference for clinical rational drug using.Methods A retrospective study on 24 ADRS induced by Imipenem-cilastatin in our hospital from January 2015 to May 2020.Results The common ADRS of Imipenem-cilastatin were delirium,restlessness,hallucinations and gastrointestinal reactions.Older patients were more susceptible and male were more than female.Conclusion The central nervous system side effect is the most common ADRS of Imipenem-cilastatin,high attention should be paid to clinical application,awareness of clinical safety medication should be increased.