复方丹参滴丸干预阿司匹林抵抗的临床效果观察

Observation on the clinical effect of compound Danshen dropping pills on aspirin resistance

目的探究复方丹参滴丸干预阿司匹林抵抗的临床效果。方法选择2020年1月~2020年6月收治的60例心血管患者为研究对象,按照干预方法不同,将其分为阿司匹林组、复方丹参组及阿司匹林+复方丹参组三组,每组20例。用药2周后,比较三组受试者干预前后APTT(活化部分凝血酶原时间)、PT(凝血酶原时间)、PLT(血小板计数)以及FIB(纤维蛋白原)的凝血指标情况。结果干预后,复方丹参+阿司匹林组APTT、PT显著变长,PLT下降,与干预前比较差异有统计学意义(P<0.05)。干预后,复方丹参组FIB比干预前低,差异有统计学意义(P<0.05)。干预前后,复方丹参组和阿司匹林组PLT指标无显著改变(P>0.05)。结论复方丹参滴丸可改善阿司匹林抵抗,应用此药能够改善患者的临床预后。

Objective To explore the clinical effect of compound Danshen dropping pills on aspirin resistance.Methods A total of 60 cardiovascular patients admitted from January 2020 to June 2020 were selected as the study subjects.According to different intervention methods,the patients were divided into three groups:aspirin group,compound Salvia miltiorrhiza group and aspirin+compound Salvia miltiorrhiza group,with 20 patients in each group.After 2 weeks of treatment,the coagulation indexes of APTT(activated partial prothrombin time),PT(prothrombin time),PLT(platelet count)and FIB(fibrinogen content)before and after intervention were compared among the three groups.Results After the intervention,APTT and PT in the compound salvia+aspirin group were significantly longer,and PLT decreased,which was significantly different from before the intervention(P<0.05).After the intervention,the FIB of the compound Danshen group was lower than that before the intervention,and the difference was statistically significant(P<0.05).Before and after the intervention,the PLT indexes of the compound salvia group and aspirin group did not change significantly(P>0.05).Conclusion Compound Danshen dripping pills can be regarded as a good preparation for aspirin resistance,and its application can improve the clinical prognosis of patients,so it is worthy of further promotion.