阿托伐他汀治疗冠心病合并高脂血症临床研究

目的探讨阿托伐他汀治疗冠心病合并高脂血症的临床疗效。方法选取医院收治的冠心病合并高脂血症患者52例,随机分为观察组与对照组,各26例。对照组进行常规基础治疗,观察组在对照组基础上给予阿托伐他汀,比较两组治疗效果。结果观察组的治疗总有效率为92.31%,明显高于对照组的65.38%(P<0.05);观察组不良反应发生率为11.54%,与对照组的7.69%相当(P>0.05);观察组患者的总胆固醇、三酰甘油、低密度脂蛋白、心绞痛发作频率等指标均明显优于对照组(P<0.05)。结论阿托伐他汀治疗冠心病合并高脂血症临床疗效和安全性均较好,对改善患者的血脂指标和心绞痛发作频率等都有重要作用。

Objective To investigate the clinical efficacy of atorvastatin in the treatment of coronary heart disease with hyperlipidemia.Methods Totally 52 patients with coronary heart disease and hyperlipidemia were randomly divided into the observation group and the control group,26 cases in each group.The control group was given routine basic treatment,and the observation group was given atorvastatin on the basis of the control group.The therapeutic effect of the two groups was compared.Results The total effective rate of the observation group was 92.31%,which was significantly higher than 65.38%of the control group(P<0.05).The incidence of adverse reactions in the observation group was 11.54%,which was similar to 7.69%in the control group(P>0.05).The indexes of total cholesterol,triacylglycerol,low-density lipoprotein,frequency of cardiac strangulation in the observation group were significantly better than those in the control group(P<0.05).Conclusion Atorvastatin has good clinical efficacy and safety in the treatment of coronary heart disease complicated with hyperlipidemia,which plays an important role in improving the blood lipid index and the frequency of angina pectoris.