更年期抑郁症患者性激素水平与认知功能的关系

Relationship between Sex Hormone Level and Cognitive Function in Patients with Menopausal Depression

为了探讨更年期抑郁症患者性激素水平与认知功能的关系,以更年期抑郁症女性患者作为病例组、正常更年期女性作为对照组,进行性激素水平测试、CogState量表认知水平评定、汉密尔顿抑郁量表等资料统计。通过比较两组激素水平发现,雌二醇无统计学差异,病例组的促黄体生成素和促卵泡生成激素水平显著低于对照组。对于两组CogState量表认知功能测定,病例组工作记忆和听觉性语言记忆明显低于对照组。对照组的认知功能视觉记忆、听觉性语言记忆与促黄体生成素水平均具有正相关性,听觉性语言记忆与促卵泡生成激素存在正相关性。但病例组各项认知指标与促黄体生成素和促卵泡生成激素水平均未发现显著相关性。结果表明:更年期女性认知功能和激素水平存在相关性,但并未能证明更年期抑郁症患者认知功能和性激素水平的明确关联。

To explore the relationship between sex hormone level and cognitive function in patients with menopausal depression,the female patients with menopausal depression and the normal menopausal women were selected as the case group and control group,respectively.The sex hormone level test,CogState battery(CSB)cognitive assessment,Hamilton depression(HAMD)scale were carried out.By comparing the hormone levels of the two groups,it was found that there was no significant difference in estradiol(E2).The levels of luteinizing hormone(LH)and follicle stimulating hormone(FSH)in the case group were significantly lower than those in the control group.The working memory(TWOB)and auditory language memory(ISL)in the case group were significantly lower than those in the control group.Cognitive function visual memory(OCL),ISL was positively correlated with LH levels in the control group,and ISL was positively correlated with FSH levels.However,there was no significant correlation between cognitive indicators with LH and FSH levels in case group.The results showed that there was a correlation between cognitive function and hormone level in menopausal women,but it failed to prove the clear correlation between cognitive function and sex hormone level in menopausal depression patients.