摘要
The Hippo signaling pathway was first discovered in Drosophila as a conserved regulator of organ size.Genetic inactivation in mice demonstrates that the Hippo pathway functions as a fundamental inhibitor of organ growth during development,and as a critical tumor suppressor in epithelial tissues.
基金
supported in part by research grants from the National Institutes of Health(AT004418 and CA106569 to TCH).
