摘要
Alzheimer’s disease(AD),the most common neurodegenerative disorder,affects millions of people worldwide.In a recent publication,Guo-Jun Chen and colleagues highlight the role of matrix metalloproteinase(MMP)13(also called Collagenase 3)in AD pathogenesis through regulating BACE1,1 a rate-limiting enzyme for b-amyloid(Ab)peptide production.2 Proteolytic processing of amyloid precursor protein(APP)by BACE1 and g-secretase generates Ab,which accumulate in brain senile plaques in AD.3 MMPs are a group of enzymes that degrade extracellular matrix and cleave proteins involved in signal transduction.
基金
Research in the Thinakaran laboratory is supported by the United States Department of Health and Human Services,National Institutes of Health grants AG054223,AG056061,and AG057290.
