摘要
Chronic hepatitis B virus(HBV)infection is one of the major health care burdens throughout the world.The chronicity of HBV infection is supported by the intracellular persistence of a multicopy viral episome called covalently closed circular DNA(cccDNA),which is the bona fide viral transcription template and resistant to currently available antivirals.1 Therefore,noncytolytic elimination of cccDNA is considered as the“holy grail”for a cure of hepatitis B,and the metabolism and transcription regulation of cccDNA have become a hot topic in basic,translational,and clinical HBV research.
