心力衰竭炎症标志物的研究进展

Research progress in inflammatory biomarkers in heart failure

心力衰竭(heart failure,HF)是各种心脏疾病的急性加重或终末期表现,HF的病理生理机制一直都是心血管领域研究的重点内容。近年来对HF炎症标志物的研究较多,如半乳糖凝集素-3(Gal-3)、可溶性肿瘤发生抑制蛋白2(s ST2)、生长分化因子-15(GDF-15)、肿瘤坏死因子-α(TNF-α)、性别决定域Y盒9(Sox9)、高迁移率蛋白-1(HMGB1)以及其他标志物等,与HF的发生中心肌肥厚、心肌纤维化等病理生理过程有密切的联系。

Heart failure is an acute aggravation or end-stage manifestation of various heart diseases,and pathophysiological mechanism of heart failure has been the focus of cardiovascular research.Recent years,there are more and more research on the inflammatory biomarkers of heart failure,such as Galectin-3(Gal-3),soluble suppression of tumorigenicity 2(sST2),growth differentiation factor-15(GDF-15),tumor necrosis factor-α(TNF-α),Sexdetermining region Y box 9(Sox9),high mobility group box-1(HMGB1)and etc.which have an intensive association to the myocardial hypertrophy and fibrosis.