IL-6和IL-19浓度预测糖尿病肾病患者动脉粥样硬化效果分析

Analysis of the effect of IL-6 and IL-19 on the prediction of atherosclerosis in diabetic nephropathy

目的探讨血清白细胞介素6(IL-6)和血清白细胞介素19(IL-9)与糖尿病肾病患者动脉粥样硬化效果发生的相关性。方法收集我院治疗的糖尿病肾病患者94例,依据是否伴有动脉粥样硬化分为硬化组和非硬化组,并选取健康体检对照组30例。收集患者基本资料和生理指标,测试患者血清IL-6和IL-19水平,分析两者与各指标相关性,并利用ROC曲线预测动脉粥样硬化发生。结果并发有动脉硬化的糖尿病肾病患者中IL-6和IL-19的水平均显著高于无动脉硬化组患者(P<0.05)。Pearson相关分析显示,IL-6水平与CRP、LDL、HbAlc及空腹血糖水平正相关(P<0.05)。IL-19水平与CRP、空腹血糖、LDL、TC水平正相关(P<0.05)。IL-6和IL-19对糖尿病肾病患者动脉粥样硬化预测最优ROC曲线下面积分别为0.77和0.85,两者联合预测其敏感性和特异性分别为0.73和0.92,预测效果最好。结论白细胞介素6(IL-6)和血清白细胞介素19(IL-9)可作为预测糖尿病肾病患者动脉粥样硬化发生的有效指标。

Objective To investigate the correlation between serum interleukin-6(IL-6)and serum interleukin-19(IL-9)and the effect of atherosclerosis in diabetic nephropathy.Methods 94 patients of diabetic nephropathy were divided into sclerotic group and non sclerotic group,according to whether there was atherosclerosis or not.The basic data and physiological indexes of patients were collected,the serum levels of IL-6 and IL-19 were measured,the correlation between the two indexes was analyzed,and the occurrence of atherosclerosis was predicted by ROC curve.Results The levels of IL-6 and IL-19 in diabetic nephropathy patients with arteriosclerosis were significantly higher than those in patients without arteriosclerosis(P<0.05).Pearson correlation analysis showed that IL-6 was positively correlated with CRP,LDL,HbAlc and fasting blood glucose(P<0.05).The level of IL-19 was positively correlated with CRP,fasting blood glucose,LDL and TC(P<0.05).The optimal area under ROC curve for predicting atherosclerosis of diabetic nephropathy patients by IL-6 and IL-19 was 0.77 and 0.85,respectively.The sensitivity and specificity of the combined prediction were 0.73 and 0.92,respectively.The prediction effect was the best.Conclusion IL-6 and IL-9 can be used as effective indexes to predict the occurrence of atherosclerosis in diabetic nephropathy.