三香汤加减治疗对功能性消化不良肝郁脾虚证患者胃肠激素的影响

Effect of modified Sanxiang Decoction on gastrointestinal hormones in patients with functional dyspepsia of liver depression and spleen deficiency syndrome

目的:探究三香汤加减治疗对功能性消化不良(FD)肝郁脾虚证患者胃肠激素的影响。方法:选择2018年10月~2019年10月入住我院的84例FD患者实施随机分组。对照组(n=42)患者接受FD常规治疗,试验组(n=42)在对照组基础上进行三香汤加减治疗。比较两组治疗效果、治疗前后胃肠激素(胃动素(MTL)、胃泌素(GAS))水平变化情况、药物相关不良反应发生情况。结果:试验组总有效率高于对照组(P<0.05);治疗后试验组组MTL、GAS水平高于同时期对照组(即P<0.05);治疗2周内,两组患者不良反应总发生率无显著差异(P>0.05)。结论:三香汤加减治疗FD患者疗效显著,可有效提高胃肠激素水平,且联合治疗方案安全性较优。

Objective:To explore the effect of modified Sanxiang Decoction on gastrointestinal hormones in patients with functional dyspepsia(FD)of liver depression and spleen deficiency syndrome.Methods:84 FD patients admitted to our hospital from October 2018 to October 2019 were randomly divided into two groups.The control group(n=42)received routine treatment of FD,and the experimental group(n=42)received modified Sanxiang Decoction on the basis of the control group.The treatment effect,the changes of gastrointestinal hormones[motilin(MTL),gastrin(gas)]levels before and after treatment,and the occurrence of drug-related adverse reactions were compared between the two groups.Results:The total effective rate of the experimental group was higher than that of the control group(P<0.05).After treatment,the levels of MTL and gas of the experimental group were higher than those of the control group(P<0.05).Within 2 weeks of treatment,there was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion:Modified Sanxiang decoction has a significant effect on FD patient,can effectively improve the level of gastrointestinal hormones,and the safety of combined treatment is better.