西罗莫司治疗淋巴管畸形的研究进展

Advances in the treatment of lymphatic malformation by Sirolimus

头颈部淋巴管畸形可能造成毁容,诱发功能性合并症,甚至危及生命。手术及药物治疗淋巴管畸形有一定效果,但复杂淋巴管畸形仍然是临床治疗难点。西罗莫司是哺乳动物雷帕霉素靶蛋白的抑制剂,可减少内皮细胞血管内皮生长因子的生成,调节血管生成、细胞增殖、迁移和粘附,在淋巴管成熟和稳定中发挥关键作用。近年临床研究提示该药物在治疗复杂淋巴管畸形治疗中有较好的应用前景,本文对其治疗机制和临床应用等研究进展进行综述。

Lymphatic malformation in oral and maxillofacial may cause malformation,induce functional complications,and even endanger life.There are many related treatment methods,but the complicated lymphatic malformation of oral and maxillofacial is still a difficult point in clinical treatment.Sirolimus is an inhibitor of mammalian target of rapamycin,which can reduce the production of vascular endothelial growth factor(VEGF)in endothelial cells,regulate angiogenesis,cell proliferation,migration and adhesion,and play a critical role in lymphatic maturation and stability.Recent clinical studies indicated that this drug has a good application prospect in the treatment of complex lymphatic malformations.This paper reviews the research progress of its therapeutic mechanism and clinical application.