摘要
头颈部鳞癌是世界上最常见的恶性肿瘤之一,其转移率高,预后差,常给患者带来严重的面部损伤,以及进食、发音等功能障碍。自然杀伤细胞是先天免疫系统的效应细胞,具有直接识别并杀死肿瘤细胞的功能。自然杀伤细胞活化水平与头颈部鳞癌的预后密切相关,头颈部鳞癌的发生发展常伴随自然杀伤细胞的数量减少或功能被抑制。重新激活自然杀伤细胞可提高头颈部鳞癌的疗效。本文就自然杀伤细胞在头颈部鳞癌发展及治疗中的应用进行综述。
Head and neck squamous cell carcinoma(HNSCC)is one of the most common malignant tumors in the world.It has a high metastasis rate and a poor prognosis.HNSCC often brings severe facial deformitiesand dysfunctions such as eating and pronunciation to patients.Nature Killer cells(NK cells)are innate immune system effector cells that directly recognize and kill tumor cells.Studies have shown that NK cells activity are associated with the prognosis of HNSCC,and HNSCC developed with the reduction or inhibition of NK cells.Previous studies believe that natural killer cells can be reactivated to improve the curative effect of HNSCC,showing the potential of natural killer cells.This article reviews the application of natural killer cells in the development and treatment of HNSCC.
作者
王鹿鸣
谢尚
Lu-Ming WANG;Shang XIE(Peking University School of Stomatology,Beijing 100081,China;Department of Oral and Maxillofacial Surgery,Peking University Hospital of Stomatology,Beijing 100081,China;National Clinical Research Center for Oral Diseases,Beijing 100081,China;National Engineering Laboratory for Digital and Material Technology of Stomatology,Beijing 100081,China;Beijing Key Laboratory of Digital Stomatology,Beijing 100081,China)
出处
《医学新知》
CAS
2021年第1期33-41,共9页
New Medicine
基金
国家自然科学基金(82002878)
北京大学口腔医院青年基金项目(YS020219)。
关键词
自然杀伤细胞
头颈部鳞癌
免疫治疗
Nature killer cells
Head and neck squamous cell carcinoma
Immunotherapy
