摘要
我国肝病多发,肝癌一直是国民健康的一大威胁,目前临床针对肝癌的防治手段效果欠佳,随着研究的不断深入,学者们将焦点转向了肿瘤微环境中的肿瘤相关成纤维细胞,越来越多的证据表明肿瘤相关成纤维细胞或可为肝癌防治提供全新靶位。现就肿瘤相关成纤维细胞在肝癌发生发展中的作用及在肝癌治疗中的潜力作一综述。
Liver cancer has always been a threat to national health since liver disease has a high incidence rate in China.At present,methods for the prevention and treatment of liver cancer have unsatisfactory effects in clinical practice,and with in-depth studies,scholars have changed their focus to cancer-associated fibroblasts(CAFs)in tumor microenvironment.More and more evidence has shown that CAFs may provide a new target for the prevention and treatment of liver cancer.This article summarizes the role of CAFs in the development and progression of liver cancer and the potential of CAFs in the treatment of liver cancer.
作者
胡晓
毛德文
牙程玉
HU Xiao;MAO Dewen;YA Chengyu(Graduate School,Guangxi University of Chinese Medicine,Nanning 530001,China;First Ward of Liver Diseases,The First Affiliated Hospital of Guangxi University of Chinese Medicine,Nanning 530023,China)
出处
《临床肝胆病杂志》
CAS
北大核心
2021年第2期444-447,共4页
Journal of Clinical Hepatology
基金
国家自然科学基金面上项目(81774236)
国家自然科学基金(81460718)
国家“十三五”艾滋病和病毒性肝炎等重大传染病防治科技重大专项(2018ZX10725504-001-008)
广西研究生教育创新计划资助项目(YCSY2020090)。
关键词
肝肿瘤
癌相关成纤维细胞
肿瘤微环境
Liver Neoplasms
Cancer-Associated Fibroblasts
Tumor Microenvironment
