非肥胖型非酒精性脂肪性肝病的病因及治疗进展

Advances in the etiology and treatment of non-obese nonalcoholic fatty liver disease

随着非酒精性脂肪性肝病(NAFLD)在非肥胖人群中的流行,越来越多的研究探讨了NAFLD在非肥胖人群中的意义。与肥胖型NAFLD患者相比,非肥胖型NAFLD患者虽缺乏肥胖表型,但仍存在代谢紊乱,其发生代谢性疾病和心血管疾病的风险更大。目前针对非肥胖型NAFLD尚无治疗相关的有效药物,且现有的治疗方式各有优势,但都存在一定的局限性。从非肥胖型NAFLD的病因及治疗进展方面进行综述,为指导非肥胖型NAFLD临床治疗提供参考。

With the prevalence of nonalcoholic fatty liver disease(NAFLD)in the non-obese population,more and more studies have explored the significance of NAFLD in such population.Compared with the patients with obese NAFLD,the patients with non-obese NAFLD lack the phenotype of obesity,but they still have metabolic disorders and higher risk of metabolic and cardiovascular diseases.At present,there are no effective drugs for the treatment of non-obese NAFLD,and the existing treatment methods have their own advantages and limitations in clinical practice.This article reviews the advances in the etiology and treatment of non-obese NAFLD,in order to provide a reference for guiding the clinical treatment of non-obese NAFLD.