胆汁酸-法尼醇核受体R-肠道微生态轴在肝衰竭发生及肝再生中的作用机制

Mechanism of action of bile acid-farnesoid X receptor-intestinal microecological axis in the development of liver failure and liver regeneration

肝衰竭是常见的内科危重症,短时间内肝细胞大面积坏死而超过肝细胞再生能力导致该病病死率极高,促进有效肝再生是拮抗肝衰竭的关键。近年来发现胆汁酸、法尼醇核受体R、肠道微生态在肝衰竭和肝再生机制中发挥重要作用。现就胆汁酸、法尼醇核受体R、肠道微生态三者之间的相关性,及三者对肝衰竭和肝再生机制的作用方面进行综述,为临床肝衰竭的治疗提供新思路。

Liver failure is a common critical medical disease,and extensive liver cell necrosis within a short period of time exceeds the regeneration capacity of liver cells and thus results in an extremely high fatality rate.Promotion of effective liver regeneration is the key to antagonizing liver failure.Recent studies have shown that bile acid,farnesoid X receptor(FXR),and intestinal microecology play an important role in liver failure and liver regeneration.This article reviews the association between bile acid,FXR,and intestinal microecology and their role in liver failure and liver regeneration,so as to provide new ideas for the treatment of liver failure in clinical practice.