甲氨蝶呤联用来氟米特治疗类风湿关节炎效果分析

目的探讨甲氨蝶呤联用来氟米特治疗类风湿关节炎的临床疗效。方法选取医院2019年5月至2020年5月收治的类风湿关节炎患者108例,按入院顺序分为对照组和观察组,各54例。两组患者均予甲氨蝶呤治疗,观察组加用来氟米特治疗,两组均持续治疗168 d。结果治疗后,观察组患者不良反应发生率、视觉模拟评分(VAS)、关节病变评分均显著低于对照组(P<0.05)。结论甲氨蝶呤联合来氟米特治疗类风湿关节炎疗效良好,可减少不良反应,改善机体关节病变症状。

Objective To investigate the clinical efficacy of methotrexate combined with flutamide in the treatment of rheumatoid arthritis.Methods Totally 108 patients with rheumatoid arthritis in our hospital from May 2019 to may 2020 were selected and divided into the control group and the observation group according to the order of admission,54 cases in each group.Both groups were treated with methotrexate,and the observation group was treated with leflunomide.Both groups were treated continuously for 168 days.Results After treatment,the incidence of adverse reactions,visual analogue scale(VAS)and joint lesion score of the observation group were significantly lower than those of the control group(P<0.05).Conclusion Methotrexate combined with leflunomide is effective in the treatment of rheumatoid arthritis,which can reduce adverse reactions and improve the symptoms of joint disease.