异常血压变异性对老年人高血压影响的研究进展

Research progress of effects of abnormal blood pressure variability on elderly patients with hypertension

老年人神经-体液-心脑血管变化调节能力下降,异常血压波动易造成患有高血压老年人的靶器官损害。研究表明异常血压变异性(BPV)是脑卒中、认知功能障碍、心血管疾病、糖尿病、肾脏疾病等疾病的危险因素。BPV同时给老年人平稳降压带来一定困难,因此临床上也应监测老年人血压变异情况。本文主要对老年人BPV与相关临床疾病以及抗高血压药物影响的研究进展进行综述。

The elderly have a decline in the regulation of neuro-humoral-cardiocerebrovascular changes,and abnormal fluctuations of blood pressure are likely to cause damage in the target organ in the elderly with hypertension.Studies show that abnormal blood pressure variability(BPV)is a risk factor of stroke,cognitive dysfunction,cardiovascular disease,diabetes,and kidney disease.At the same time,BPV results in difficulty in steady reduction of blood pressure;therefore,it is necessary to monitor clinically the blood pressure variation in the elderly.This article reviews the research progress in BPV,associated diseases and influence of anti-hypertensive drugs in the elderly.