艾灸联合脾氨肽对反复呼吸道感染非急性感染期患儿免疫功能的影响观察

Effect of Moxibustion Combined with Spleen Aminopeptide on Immune Function for Children with Recurrent Respiratory Tract Infection at Non-acute Infection Stage

目的:观察艾灸联合脾氨肽对反复呼吸道感染(RRTI)非急性感染期患儿体液免疫功能和临床疗效的影响。方法:选取2016年2月~2019年2月本院门急诊收治的非急性感染期RRTI患儿106例,随机数表法分为观察组(n=53)和对照组(n=53)。对照组给予脾氨肽冻干粉治疗,观察组在此基础上行艾灸疗法,连续治疗1个月,随访6个月,比较两组患儿的临床疗效、治疗前后的呼吸道感染次数、免疫球蛋白、T淋巴细胞亚群水平和治疗期间不良反应发生情况。结果:观察组的治疗总有效率为90.57%高于对照组的75.47%(P<0.05);治疗后,两组患儿半年内呼吸道感染次数均减少(P<0.05),且观察组的感染次数低于对照组(P<0.05);治疗后,两组患儿的血清IgG、IgA和IgM水平明显上升(P<0.05),且观察组的血清IgG、IgA和IgM水平高于对照组(P<0.05);治疗后,两组患儿的CD3^(+)、CD4^(+)和CD4^(+)/CD8^(+)水平明显上升,CD8^(+)水平明显下降(P<0.05),且观察组的CD3^(+)、CD4^(+)和CD4^(+)/CD8^(+)水平高于对照组,CD8^(+)水平低于对照组(P<0.05);治疗期间,两组患儿的不良反应总发生率比较,差异无统计学意义(P>0.05)。结论:艾灸联合脾氨肽在治疗非急性感染期RRTI方面疗效确切,可有效增强患儿的机体免疫功能,降低呼吸道感染复发次数,安全可靠,值得临床推广与应用。

Objective: To investigate the effect of moxibustion combined with spleen aminopeptide on the humoral immune function for children with recurrent respiratory tract infection(RRTI) at non-acute infection stage. Methods: A total of 106 children with non acute infectious RRTI admitted to our hospital from February 2016 to February 2019 were randomly divided into an observation group(n=53) and a controlled group(n=53). The controlled group were treated with Spleen Aminopeptide Lyophilized Powder, and the observation group was treated with moxibustion combined with spleen aminopeptide. Both groups were treated for 1 month and were followed up for 6 months. The clinical effect, the frequency of respiratory tract infections before and after treatment, levels of immunoglobulin and T-lymphocyte subsets and the occurrence of adverse reactions during treatment were compared between the two groups. Results: The total effective rate of treatment in the observation group(90.57%) was higher than that in the controlled group(75.47%)(P<0.05). After treatment, the frequency of respiratory tract infections decreased within half a year(P<0.05),and the frequency of infections in the observation group was lower than the controlled group(P<0.05). After treatment, the serum IgG,IgA and IgM levels increased significantly(P<0.05),and the above levels in the observation group were higher than the controlled group(P<0.05). After treatment, the CD3^(+),CD4^(+) and CD4^(+)/CD8^(+) increased significantly, and the CD8^(+) decreased significantly(P<0.05). CD3^(+),CD4^(+) and CD4^(+)/CD8^(+) in the observation group were higher than the controlled group, and CD8^(+) was lower than the controlled group(P<0.05). There was no statistically significant difference in the total incidence of adverse reactions between the two groups during treatment(P>0.05). Conclusion: Moxibustion combined with spleen aminopeptide is effective in the treatment of RRTI at non-acute infection stage. It can effectively enhance the immune function of children and reduce the recurrence frequency of respiratory tract infections. It is safe and reliable, and is worthy of clinical promotion and application.