阳性淋巴结对数比对Ⅲ期结直肠癌预后的预测价值

Investigate the prognostic value of LODDS in stageⅢcolorectal cancer

目的探讨阳性淋巴结对数比(log odds of positive lymph nodes,LODDS)对Ⅲ期结直肠癌预后的预测价值。方法收集177例结直肠癌患者相关临床病理资料,记录患者的阳性淋巴结数、阴性淋巴结数,计算LODDS,按LODDS四分位数将患者分为四组,所有患者均完成5年的随访。结果四组患者在5年随访中,生存率分别为75.0%、57.1%、46.9%、43.2%。随着LODDS的增长,生存率也呈降低趋势。相对于LODDS最低四分位的患者,LODDS最高四分位患者的5年生存率明显下降(75.0%比43.2%,P<0.001)。多因素Cox回归分析表明LODDS、组织分化程度是Ⅲ期结直肠癌患者5年生存的独立预后因子。结论LODDS为Ⅲ结直肠癌的5年生存率的独立预后指标。

ObjectiveTo investigate the prognostic value of log odds of positive lymph nodes(LODDS)in stageⅢcolorectal cancer.MethodsThe clinic-pathological data of 177 patients with colorectal cancer was collected,the number of positive and negative lymph nodes were collected,and the LODDS were calculated,then patients were divided into four groups according to the quartile of LODDS.Patients were followed up for 5 years.ResultsThe 5-year survival rates of the four groups were 75.0%,57.1%,46.9%and 43.2%respectively.With the increase quartile of LODDS,the survival rate also decreased.Compared with patients with the lowest quartile of LODDS,the 5-year survival rate of patients with the highest quartile of LODDS decreased significantly(75.0%vs 43.2%,log rank P<0.001).Multivariate analysis showed that only LODDS and the degree of tissue differentiation were independent prognostic factors.ConclusionThe results of this study show that LODDS is an independent prognostic factor for stageⅢcolorectal cancer.