99mTc-DTPA肾动态显像技术在糖尿病肾病肾损害诊断中的应用

Application of Tc-DTPA Renal Dynamic Imaging in the Diagnosis of Renal Damage in Diabetic Nephropathy

目的:研究99mTc-DTPA肾动态显像技术在糖尿病肾病肾损害诊断中的应用,为患者的恢复提供临床指导。方法:选取本院2018年1月-2020年1月接诊的120例糖尿病肾病患者作为研究对象。根据尿白蛋白含量不同将其分为正常白蛋白尿组(NA组)、微量白蛋白尿组(MA组)、大量白蛋白尿组(MAA组),每组40例,另选40例健康人员作为对照组,记录各组年龄、病程、体质指数(BMI)、收缩压(SBP)、舒张压(DBP)、糖化血红蛋白(HbA1c),以及血肌酐(Scr)、肾小球滤过率(GFR)、肾功能曲线峰时、20 min残留率肾功能相关指标,并对Scr与GFR作相关性分析。结果:四组年龄、BMI指标相比,差异无统计学意义(P>0.05)。NA组病程明显短于MA组,MA组病程明显短于MAA组,差异有统计学意义(P<0.05)。NA组SBP、DBP、HbA1c明显高于对照组,MA组明显高于NA组,MAA组明显高于MA组,差异有统计学意义(P<0.05)。NA组Scr、肾功能曲线峰时、20 min残留率均明显高于对照组,MA组明显高于NA组,MAA组明显高于MA组,差异有统计学意义(P<0.05)。NA组GFR明显低于对照组,MA组明显低于NA组,MAA组明显低于MA组,差异有统计学意义(P<0.05)。99mTc-DTPA肾动态显像GFR与糖尿病肾病患者Scr检测结果相关性分析显示,GFR与Scr呈负相关(r=-0.375,P=0.017)。结论:99mTc-DTPA肾动态显像技术在糖尿病肾病肾损害诊断中,可准确反映糖尿病肾病患者肾功能状态,操作简单无创,对糖尿病肾病的早期诊断和预防具有重要的指导意义,具有临床应用价值,值得推广。

Objective:To study the application of 99mTc-DTPA renal dynamic imaging in the diagnosis of renal damage in diabetic nephropathy,and to provide clinical guidance for the recovery of patients.Method:A total of 120 patients with diabetic nephropathy in our hospital from January 2018 to January 2020 were selected as the research objects.They were divided into the normal albuminuria group (NA group),the microalbuminuria group (MA group) and the macroalbuminuria group (MAA group) according to the difference of microalbuminuria content,40 cases in each group.And 40 healthy people were selected as the control group.The age,course of disease,body mass index (BMI),systolic blood pressure (SBP),diastolic blood pressure (DBP),glycosylated hemoglobin (HbA1c) and renal function related indicators such as urinary albumin,serum creatinine (Scr),glomerular filtration rate (GFR),peak time of renal function curve and 20 min residual rate were recorded.The correlation between Scr and GFR was analyzed.Result:There were no significant differences in age and BMI between the four groups (P>0.05).The course of disease in the NA group was significantly shorter than that in the MA group,the course of disease in the MA group was significantly shorter than that in the MAA group,and the differences were statistically significant (P<0.05).The SBP,DBP and HbA1c in the NA group were significantly higher than those in the control group,the SBP,DBP and HbA1c in the MA group were significantly higher than those in the NA group,the MAA group was significantly higher than the MA group,the differences were statistically significant (P<0.05).The Scr,peak time of renal function curve,20 min residual rate in the NA group were significantly higher than those in the control group,the MA group was significantly higher than that in the NA group,and the MAA group was significantly higher than that in the MA group (P<0.05).The GFR of the NA group was significantly lower than that of the control group,the MA group was significantly lower than the NA group,the MAA group was significantly lower than that of the MA group,the differences were statistically significant (P<0.05).99mTc-DTPA renal dynamic imaging GFR results and SCR detection results in patients with diabetic nephropathy correlation analysis showed that GFR was negatively correlated with Scr(r=-0.375,P=0.017).Conclusion:99mTc-DTPA renal dynamic imaging technology in the diagnosis of diabetic nephropathy renal damage can accurately reflect the state of renal function of diabetic patients,simple and noninvasive operation,has important guiding significance for the early diagnosis and prevention of diabetic nephropathy,has clinical application value,and is worth promoting.