短瓣金莲花解热镇痛作用研究

Antipyretic and Analgesic Action Research of the Effective Parts of Trollius ledebourii Reichb

目的研究短瓣金莲花其有效部位的解热镇痛作用。方法镇痛作用的实验方法是采用小鼠热板法测定给药后小鼠的痛域值。解热作用的实验方法是采用大鼠皮下注射2,4-二硝基苯酚溶液,检测造模后大鼠体温变化。结果短瓣金莲花高剂量组给药30 min左右后发挥作用,1 h左右作用最强,其效果一直持续至90 min;中剂量组和低剂量组的镇痛作用比高剂量组弱;中剂量组与低剂量组数据进行对比后,发现镇痛作用缓慢增强至90 min,且90 min之后逐渐减弱。随短瓣金莲花有效部位的剂量增加,解热作用增强。结论短瓣金莲花有效部位具有解热镇痛作用。

OBJECTIVE To study the antipyretic and analgesic effects of the effective parts of Trollius ledebourii Reichb.METHODS The experimental method of analgesic effect is to use mouse hot plate method to determine the pain threshold of mice after administration.The experimental method of antipyretic effect is to use rats to subcutaneously inject 2,4-dinitrophenol solution to detect changes in rat body temperature after modeling.RESULTS The high-dose group of short-pet al golden lotus exerted its effects after about 30 minutes of administration,the strongest effect was about 1 hour,and its effect lasted 90 minutes;the analgesic effect of the middle-dose group and the low-dose group was weaker than the high-dose group;After comparing with the data of the low-dose group,it was found that the analgesic effect slowly increased to 90 minutes,and gradually decreased after 90 minutes.With the increase of the dose of the effective part of the short pet al nasturtium,the antipyretic effect is enhanced.CONCLUSION The effective part of Trollius ledebourii Reichb.has antipyretic and analgesic effects.