信号通路调控子宫内膜异位症的研究进展

Advances in Research on Signaling Pathways Regulation of Endometriosis

子宫内膜异位症(EMs)是育龄妇女中的常见病、疑难病,发病机制错综复杂,极具侵袭性,易转移和复发,治疗效果不甚满意,而针对其发生发展机制的研究,寻找有效治疗方法是目前妇科领域研究的焦点。近年来研究发现,异位内膜细胞的上皮间质转化、黏附侵袭和血管生成过程是EMs发生发展中的重要机制,在此过程中有多条信号通路的调控,如转化生长因子β(TGF-β)/Smad、Notch、核因子κB(NF-κB)、Wnt/β连环蛋白(β-catenin)、磷脂酰肌醇3激酶/蛋白激酶B/哺乳动物雷帕霉素靶蛋白(PI3K/Akt/mTOR)。阐述EMs发病过程中涉及的相关信号通路研究,为临床防治EMs提供新的思路。

Endometriosis(EMs)is a common and difficult disease in women of childbearing age with complex pathogenesis.It is extremely invasive,easy to metastasize and relapse,and the therapeutic effect is not satisfactory.The research on the mechanism of its occurrence and development and the search for effective treatment is the focus of gynecological research.In recent years,studies have found that the processes of epithelial-mesenchymal transition,adhesion invasion and angiogenesis of ectopic endometrial cells are important mechanisms in the occurrence and development of EMs.There are many signal pathways in this process,such as transforming growth factorβ(TGF-β)/Smad,Notch,nuclear factorκB(NF-κB),Wnt/β-catenin,phosphatidyl inositol 3 kinase/protein kinase B/mammalian target of rapamycin(PI3 K/Akt/mTOR).In this paper,the related signal pathways involved in the pathogenesis of EMs were described to provide a new idea for clinical prevention and treatment of EMs.