间隙连接蛋白43与胎膜早破的相关性

Connexin 43 and Premature Rupture of Membranes Related Problems

胎膜早破(premature rupture of membranes,PROM)是产科最常见的早产原因之一,可诱发新生儿呼吸窘迫综合征、绒毛膜羊膜炎、胎盘早剥、败血症等不良结局。间隙连接通讯是细胞间最常见的信息交互及物质交换途径,其功能主要由间隙连接蛋白实现,间隙连接蛋白43(Connexin43,Cx43)是间隙连接蛋白家族中最常见且最重要的一类间隙连接蛋白,Cx43的半通道结构可在细胞间进行连接,形成细胞间的完整传输通道,在细胞间缝隙连接、细胞间信息和物质交流及胎膜完整性中发挥重要作用,Cx43在胎膜中的表达与胎膜中Ⅰ、Ⅲ型胶原表达水平有密切关系,并可通过影响Ⅰ、Ⅲ型胶原数量及交联方式而致胎膜薄弱,进而导致胎膜早破。Cx43降低可致胎膜微裂隙发生及扩大进而导致胎膜早破发生,本文就Cx43与胎膜早破的相关性进行综述,以期对胎膜早破的发生机制及防治有进一步认识。

Premature rupture of membranes(PROM)is one of the most common causes of preterm delivery in obstetrics,which can induce poor prognosis,such as neonatal respiratory distress syndrome,chorioamnionitis,placental abruption,septicemia and so on.Gap junction communication is the most common way of information exchange and material exchange between cells.Its function is mainly realized by gap junction proteins.Connexin43(Cx43)is the most common and important protein in the gap junction family,Cx43 can connect cells to form a complete transmission channel between cells,which plays an important role in intercellular gap junction,the exchange of information and materials between cells,and fetal membrane integrity.It is closely related to the levels of type I and III collagen in fetal membranes,which can cause weakening of the fetal membranes by affecting the amount of type I and III collagen and the cross-linking method,lead to premature rupture of the fetal membranes.The decrease of Cx43 can lead to the occurrence and expansion of fetal membrane microfissures and lead to premature rupture of fetal membranes.This article reviews the correlation between Cx43 and premature rupture of membranes in order to have a better understanding of the mechanism,prevention and treatment of premature rupture of membranes.