结构和功能MRI预测脑震荡后综合征的研究进展

Progresses of structural and functional MRI in predicting post-concussion syndrome

轻度创伤性脑损伤(mild traumatic brain injury,mTBI)是脑损伤最常见的类型,mTBI发生后患者有短暂的意识丧失、失忆及精神状态改变。大部分患者的症状在短期内恢复,部分患者的不适症状持续存在,发展为脑震荡后综合征(post-concussion syndrome,PCS)。PCS的出现严重影响患者的日常工作和生活,但目前PCS的病理生理机制尚不明确。随着先进的MRI技术的发展,越来越多的研究探索mTBI的脑微观结构和功能改变,探讨PCS的发生机制并对其进行预测。笔者从脑结构和功能MRI对mTBI的异常发现进行综述。

Mild traumatic brain injury(mTBI)is the most common type of brain injury.After an accident,patients have short-term loss of consciousness,amnesia and mental state changes.Most patients'symptoms recovered in a short time,while some patients'discomfort persisted and developed into post-concussion syndrome(PCS).The appearance of PCS seriously affects patients'daily work and life,but the pathophysiological mechanism of PCS is still unclear.With the development of advanced MRI technology,more and more researches have explored the brain microstructure and functional changes of mTBI,discussed the mechanism of PCS and predicted PCS.