多发性硬化磁共振影像组学定量研究进展

Research progress of quantitative MRI radiomics in multiple sclerosis

多发性硬化(multiple sclerosis,MS)的发病率在全球范围内逐渐呈上升趋势,目前认为MS是复杂的基因-环境因素所致,但具体发病机制仍然不详。早发现早治疗是延缓或降低MS致残率的重要手段。随着技术的进步和新序列的出现,MRI在多发性硬化的诊断及监测进展的临床价值等方面显得更为重要。先进的MRI技术有助于进一步探索MS的发病机制,目前新的观点认为MS是一种颅脑异构性过程,其特征是中枢神经系统广泛受损,而不仅仅是脑白质多发局灶性脱髓鞘。磁共振定量技术可以为广泛性疾病受损的假设提供可靠的支持,其相关定量指标被认为是轴突功能障碍的特异性标志。笔者就近些年来颅脑磁共振定量技术在MS的应用研究进展进行阐述。

The incidence of multiple sclerosis(MS)is on the rise globally.MS is believed to be caused by complex gene-environmental factors,but the specific pathogenesis is still unknown.Early detection and treatment is an important means to delay or reduce MS disability rate.With the development of technology and the emergence of new sequences,MRI becomes more important in the diagnosis of multiple sclerosis and the clinical value of monitoring the progress.Advanced MRI techniques are helpful to further explore the pathogenesis of MS.Currently,MS is considered as a brain isomerism process characterized by extensive damage to the central nervous system and not just multiple focal demyelination of the white matter.Quantitative magnetic resonance imaging(qMRI),which is considered a specific marker of axonal dysfunction,can reliably support the hypothesis of generalized disease impairment.In this paper,the application of craniocerebral qMRI in MS in recent years is reviewed.