CYP2B6基因多态性与成年人急性髓系白血病易感性的相关性

The relationship between the polymorphism of CYP2B6 gene and the susceptibility of acute myeloid leukemia in adults

目的探讨CYP2B6基因多态性与成年人急性髓系白血病(AML)易感性的相关性。方法选取87例首次确诊AML的患者作为AML组,191例健康体检者作为对照组,运用Sanger测序法对CYP2B6785A>G与516G>T两个单核苷酸多态性位点进行基因分型。结果CYP2B6785A>G位点在显性模型下(AG+GG vs.AA,P<0.05,OR=5.34,95%CI:4.05~7.04)和携带等位基因G(G vs.A,P<0.05,OR=2.22,95%CI:1.46~3.37)均会增加患AML的风险。CYP2B6516G>T位点在显性模型下(GT+TT vs.GG:P>0.05,OR=0.70,95%CI:0.41~1.19)和携带等位基因T(G vs.T,P>0.05,OR=0.73,95%CI:0.47~1.15)均与AML患病风险无关。结论CYP2B6785A>G位点携带等位基因G可能会增加AML患病风险。

Objective To discuss the susceptibility of gene polymorphism of CYP2B6 to the acute myeloid leukemia(AML)in adults.Methods Using Sanger sequencing technology to identify the genotypes of 785A>G and 516G>T of CYP2B6 in 87 first-diagnosed AMI patients(AMI group),meanwhile 191 healthy volunteers were enrolled as the control group.Results CYP2B6785A>G in the dominant model(AG+GG vs.AA,P<0.05,OR=5.34,95%CI:4.05-7.04)and with allele G(G vs.A,P<0.05,OR=2.22,95%CI:1.46-3.37)both increased the risk of AML.CYP2B6516G>T did not affect the risk of AML in the dominant model(GT+TT vs.GG,P>0.05,OR=0.70,95%CI:0.41-1.19)or with allele T(G vs.T,P>0.05,OR=0.73,95%CI:0.47-1.15).Conclusion CYP2B6785A>G with allele G might increase the risk of AML in adults.