涤纶/蚕丝机织心脏瓣膜的制备及其性能

Preparation and performance of polyester/silk woven heart valve

为研制具有优良力学性能和抗血液渗透性能的人工心脏瓣膜,采用涤纶(PET)长丝和脱胶蚕丝(SF),选取不同组织结构、纱线线密度和织物经纬密等参数,在小型织机上通过优化设计试验制备了PET/SF机织人工心脏瓣膜织物(AHVF),并探讨对人工瓣膜的定制化设计。结果表明:制备的AHVF的厚度小于(0.52±0.1)mm,具有良好的亲水性,水接触角为60°±1.2°,接近于自体心脏瓣膜;AHVF的力学性能具有各向异性特征,经向弹性模量为60~100 MPa,经向断裂强度为20~40 MPa,纬向弹性模量为7~50 MPa,纬向断裂强度为7.5~20 MPa,水渗透性低于300 mL/(cm2·min),达到了心脏瓣膜的标准,具备作为心脏瓣膜的可能。

In order to develop an artificial heart valve with required mechanical properties and blood-proof performance,polyester(PET)multifilament and degummed silk fibroin(SF)were used for preparing woven artificial heart valve fabric(AHVF)through optimized design experiments on a sample weaving machine,with different structures,yarn linear densities and fabric densities.The optimization results show that when the thickness of AHVF is as thin as(0.52±0.1)mm,the AHVF demonstrates good hydro-philicity with contact angel of(60°±1.2°)which is closed to human heart valve.It is shown that AHVF has anisotropic mechanical properties and low permeability,with warp elastic modulus being 60~100 MPa,warp breaking strength 20~40 MPa,weft elastic modulus 7~50 MPa,weft breaking strength 7.5~20 MPa,and water permeability lower than 300 mL/(cm2·min).Such properties of AHVF meet the standards for heart valve materials,indicating the feasibility of the AHVF for heart valve application.