超声神经调控钾通道治疗疼痛的研究进展

Research progress of ultrasonic neuroregulation of potassium channels in the treatment of pain

神经性疼痛不仅影响患者的生活质量,甚至威胁生命,临床难以治愈。背根神经节神经元是神经性疼痛发生和维持的主要解剖部位,其钾离子通道与动作电位的放电频率和由此产生的神经元活动有着密不可分的联系;超声波可以作用于体外单独的细胞离子通道,又可以作用于体内局部组织的离子通道,使其开闭。基于超声的神经调控是一种治疗中枢及外周神经性疼痛很有潜力的方法。本文就钾离子通道作为治疗神经性疼痛的超声靶点机制及研究现状进行综述。

Neuropathic pain is difficult to treat clinically,which not only affects the patient’s quality of life,but even threatens patient’s life.Dorsal root ganglion(DRG)neurons are the main anatomic sites for the occurrence and maintenance of neuropathic pain,and the potassium channels of DRG neurons are closely related to the firing frequency of action potential and the neuronal activities.Ultrasound can act on the ion channels of individual cells in vitro and the ion channels in local tissues in vivo to make them open or close.In this paper,the mechanism and research status of potassium channel as ultrasound target for the treatment of neuropathic pain are reviewed.