氧化应激反应性miRNA靶向调控Nrf2-ARE信号通路在眼底疾病发生发展中的作用

Role of oxidative stress-responsive miRNA targeting regulation of Nrf2-ARE signaling pathway in the development of fundus diseases

核因子E2相关因子2-抗氧化反应原件复合体(nuclear factor erythroid 2 related factor 2,Nrf2-antioxidant response element,ARE)是一种重要的内源性抗氧化应激通路,能够调节细胞内众多抗氧化物的表达,具有维持细胞氧化-抗氧化平衡、抑制凋亡、抗炎等多种生物活性。微小RNA(microRNA,miRNA)是真核生物中广泛存在的能调节基因表达的一类非编码、极短小RNA分子。多种氧化应激反应性miRNA可直接或间接作用于Nrf2-ARE信号通路并调控相关基因的表达,促进或抑制视网膜氧化损伤及眼底退行性变等疾病的发生发展。(国际眼科纵览,2020,44:443-447)

Nrf2-ARE is an important anti-oxidative stress pathway,which can regulate the expression of many antioxidants in cells,and has a variety of biological activities such as maintaining cell oxidation-antioxidant balance,inhibiting apoptosis,and anti-inflammatory.MicroRNAs(miRNAs)are a type of non-coding and extremely short RNA molecules that are widely present in eukaryotes which can regulate gene expression.It has been found that a variety of miRNAs can directly or indirectly act on the Nrf2-ARE signaling pathway and regulate the expression of related genes,promoting or inhibiting the occurrence and development of retinal oxidative damage and fundus degeneration.(Int Rev Ophthalmol,2020,44:443-447)