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靶组织中关键信号分子的异常表达在近视发生发展中的作用

The role of abnormal expression of key signal molecules in target tissues in the occurrence and development of myopia
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摘要 在近视发生发展过程中,眼球各层组织出现特殊的病理变化,主要表现为视网膜色素上皮变薄、脉络膜萎缩、巩膜变薄。诸多信号分子如多巴胺、乙酰胆碱、胰高血糖素、细胞生长因子的表达与变化最终作用于视网膜、脉络膜和巩膜组织,引起近视性病理改变。然而,一些重要信号分子的信息传递通路及具体靶点仍不明确,有待进一步研究。(国际眼科纵览,2020,44:448-452) During the development of myopia,there are special pathological changes in each layer of the eyeball,which are mainly manifested as thinning of the retinal pigment epithelium,choroidal atrophy,thinning of sclera.The expression and changes of many signaling molecules,such as dopamine,acetylcholine,glucagon,and cell growth factors,which eventually act on the retina,choroid and sclera tissue,causing myopic pathological changes.However,the information transmission pathways and specific targets of some important signal molecules are still unclear,further research is needed.(Int Rev Ophthalmol,2020,44:448-452)
作者 迟晴晴 江峰 Chi Qingqing;Jiang Feng(Shanghai Eye Disease Prevention and Treatment Center,Shanghai 200040,China)
出处 《国际眼科纵览》 2020年第6期448-452,共5页 International Review of Ophthalmology
基金 上海市卫生与计划生育委员会青年科研项目(2017Y0207)。
关键词 近视 视网膜色素上皮 脉络膜 巩膜 myopia retinal pigment epithelium choroid sclera
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