纳米晶作为眼部药物递送系统的研究进展

Progress of Nanocrystal as Ophthalmic Drug Delivery System

纳米晶组成简单、毒副作用小、可延长药物眼表滞留时间、促进药物角膜透过、从而提高眼部生物利用度。纳米晶作为眼部药物传递系统的研究已成为新的趋势,其有望成为一类成熟的眼部药物传递系统。笔者广泛查阅近年的文献资料、进行分析、综合,归纳新型眼用纳米晶制剂的特点,综述其作为眼部药物传递系统的研究进展。

We concluded the characteristics of new formulations of ophthalmic nanocrystal and summarized the research development of nanocrystal as ophthalmic drug delivery system. Literature data in recent years were extensively consulted, analyzed, synthesized and summarized to illustrate its advantages in ocular application. The nanocrystal with simple ingredients has little side-effects. It can prolong the retention of drug substance on ocular surface and promote corneal penetration, thus improving the ocular bioavailability. The research of nanocrystal as an ophthalmic drug delivery system has become a new trend, and it is expected to be a promising ophthalmic drug delivery system.