轻度行为损害的量表评估及与载脂蛋白E基因多态性的关系研究

Relationship of mild behavioral impairment checklist-assessed mild behavioral impairment and apoE gene polymorphism

目的对中国轻度行为损害(MBI)人群进行量表评估,并探索其发病与载脂蛋白E(apoE)基因多态性的关系。方法选择华东医院神经内科门诊及住院的老年MBI患者34例(MBI组),另选择健康体检者30例(对照组)。2组完成轻度行为损害清单(MBI-C)等量表评估及apoE基因型测定,并比较各基因型人群的差异。MBI-C评分包括兴趣、动机和动力,情绪和焦虑症状,延迟满足和自我控制,社交规范,坚定的信念和感觉体验5个维度。结果MBI组MBI-C评分(8.50±2.69)分。最常见的临床表现为情绪和焦虑症状31例(91.2%),MBI-C评分2(2,4)分。MBI组携带apoEε2等位基因比例明显低于对照组(5.9%vs 30.0%,P=0.011),MBI-C评分与是否携带apoEε2无关。携带apoEε4的MBI患者MBI-C总分明显高于未携带apoEε4的MBI患者[(9.64±2.16)分vs(7.65±2.55)分,P=0.033]。结论MBI患者最常见的的临床表现为情绪失调、冲动控制障碍和动机减退。apoEε2等位基因携带者的患有MBI的比例较低。携带ε4的MBI患者倾向于有更严重的临床症状。

Objective To study the relationship of mild behavioral impairment checklist(MBI-C)-assessed BMI and apoE gene polymorphism.Methods Thirty-four elderly MBI patients admitted to our hospital from January 2019 to January 2020 served as a MBI group and 30 persons undergoing physical examination in our hospital during the same period served as a control group.Their MBI was assessed according to their MBI-C score.Their apoE genotypes were detected and compared.The MBI-C scores were consisted of interest score,motive and motive force score,emotion and anxiety score,delayed satisfaction and self control score,social intercourse standard score,firm conviction and sensation experience score.Results The MBI-C score was 8.50±2.69 in MBI group.The most common clinical manifestations of 31 elderly MBI patients(91.2%)were emotion maladjustment and anxiety with a MBI-C score of 2.The distribution frequency of ε2 allelic gene was significantly lower in MBI group than in control group(5.9%vs 30.0%,P=0.011).The MBI-C score was not related with the apoE carrying or not carrying ε2 allelic gene.The total MBI-C score was significantly higher in MBI patients carrying ε4 allelic gene than in those not carrying ε4 allelic gene(9.64±2.16 vs 7.65±2.55,P=0.033).Conclusion The most common clinical manifestations of MBI patients are emotion maladjustment,impulsion control disturbance and motive reduction.The incidence of MBI is relatively low in apoE2 allelic gene carriers.The BMI patients carrying ε4 allelic gene show a tendency to present severer clinical symptoms.