诱导化疗联合同步放化疗治疗局部晚期非小细胞肺癌临床效果研究

Study on the clinical effect of induction chemotherapy combined with concurrent chemoradiotherapy in the treatment of locally advanced non-small cell lung cancer

目的研究给予局部晚期非小细胞肺癌(non-small cell lung cancer,NSCLC)患者诱导化疗联合同步放化疗和单纯同步放化疗的临床疗效。方法于局部晚期NSCLC患者中抽取56例,随机分为两组,对照组给予单纯同步放化疗,观察组增加诱导化疗。对比两组患者临床疗效、生存率以及毒副作用。结果观察组治疗总有效率高于对照组(P<0.05),1年生存率、2年生存率和3年生存率均高于对照组(P<0.05)。两组患者恶心呕吐发生率比较,差异无统计学意义(P>0.05);观察组患者骨髓抑制和放射性食管炎发生率均高于对照组(P<0.05)。结论对于局部晚期NSCLC患者给予诱导化疗联合同步放化疗,临床疗效好于单纯同步放化疗,但治疗毒副作用显著增加,在临床应用中应当全面评估患者病情,谨慎使用。

Objective To study the clinical efficacy of induction chemotherapy combined with concurrent chemoradiotherapy and single concurrent chemoradiotherapy in patients with locally advanced non-small cell lung cancer(NSCLC).Methods Fifty-six patients with locally advanced NSCLC were selected and randomly divided into two groups.The control group was treated with single concurrent chemoradiotherapy,and the observation group was treated with induction chemotherapy combined with concurrent chemoradiotherapy.The clinical efficacy,survival rate and toxic side effects of the two groups of patients were compared.Results The total effective rate of treatment in the observation group was higher than that in the control group(P<0.05),and the 1-year survival rate,2-year survival rate and 3-year survival rate were higher than those in the control group(P<0.05).There was no significant difference in the incidence of nausea and vomiting between the two groups(P>0.05).The incidence of bone marrow suppression and radiation esophagitis in the observation group were higher than those in the control group(P<0.05).Conclusion For locally advanced NSCLC patients given induction chemotherapy combined with concurrent chemoradiation,the clinical efficacy is slightly better than that of concurrent radiotherapy alone,but the side effects of the treatment are significantly increased.In clinical applications,the patient’s condition should be fully evaluated and used with caution.