活血逐瘀清毒汤治疗脓毒症所致急性肾损伤的疗效及对心血管事件的影响

Curative Efficacy of Huoxue Zhuyu Qingdu Decoction(活血逐瘀清毒汤)on Patients with Acute Kidney Injury Induced by Sepsis and Its Effect on Cardiovascular Events

目的:探讨活血逐瘀清毒汤治疗脓毒症致急性肾损伤患者的疗效及对心血管事件的影响。方法:选择脓毒症致急性肾损伤患者112例,按随机数字表法分为对照组和观察组各56例。对照组给予常规疗法,观察组在对照组治疗基础上联合活血逐瘀清毒汤治疗。治疗1个月后,比较两组患者急性生理学与慢性健康状况评分表(APACHEⅡ)评分、序贯器官衰竭估计(SOFA)评分,以及炎症因子、肾损坏物、治疗后期情况。结果:经过1个月治疗后,两组患者APACHEⅡ、SOFA评分均下降(P<0.05),组间比较观察组评分低于对照组(P<0.05);两组患者各项指标均下降,观察组指标下降幅度低于对照组(P<0.05);两组患者的血肌酐(SCr)、半胱氨酸蛋白酶抑制剂C(Cys-C)、中性粒细胞明胶酶相关脂质运载蛋白(NGAL)数据均下降(P<0.05),观察组下降程度优于对照组(P<0.05);观察组患者住院时间等情况优于对照组(P<0.05),且观察组心血管事件发生率低于对照组(P<0.05)。结论:活血逐瘀清毒汤应用于治疗脓毒症所致急性肾损伤患者,能减轻患者痛苦,降低心血管事件发生率,并发症较少。

Objective:To investigate the curative efficacy of Huoxue Zhuyu Qingdu Decoction(活血逐瘀清毒汤)on patients with acute kidney injury caused by sepsis and its effect on cardiovascular events.Methods:A total of 112 patients with acute kidney injury caused by sepsis were enrolled.According to the random number table method,they were divided into the control group and the observation group.The control group was treated with conventional methods.The observation group was treated with Huoxue Zhuyu Qingdu Decoction on the basis of the treatment of the control group.After 1 month of treatment,the APACHE II and SOFA scores of the two groups were compared,and the inflammatory factors,the renal damage,and the status at the late stage of treatment of the two groups were compared.Results:After one month of treatment,the APACHEII and SOFA scores of the two groups were both decreased(P<0.05),but the scores of the observation group were significantly lower than those of the control group(P<0.05).The other indexes of the two groups were decreased,but the decrease degree of the indexes of the observation group was significantly lower than that of the control group(P<0.05).The SCr,Cys-C and NGAL of the two groups were decreased(P<0.05),but the decrease degree of the observation group was significantly greater than that of the control group(P<0.05).The hospitalization time and other status of the observation group was better than those of the control group(P<0.05).The incidence of cardiovascular events in the observation group was lower than that in the control group(P<0.05).Conclusions:The application of Huoxue Zhuyu Qingdu Decoction can alleviate the suffering of patients,reduce the incidence of cardiovascular events in patients with acute kidney injury induced by sepsis,and has less complications.