黄芪甲苷对心脏保护作用的研究现状

Current situation of protective effect of AstragalosideⅣon cardiac

黄芪甲苷通过抑制核因子-кB(NF-кB)通路、降低NF-кB的表达水平来抑制缺氧心肌细胞的凋亡。黄芪甲苷通过调节自噬基因、上调B细胞淋巴瘤/白血病-2基因(Bcl-2),降低Bcl-2相关X蛋白(Bax)及半胱氨酸蛋白酶(caspase)-3的表达以及上调低氧诱导因子-1α(HIF-1α)表达等途径对缺血再灌注心脏发挥保护作用。黄芪甲苷也可降低心肌转化生长因子β1(TGF-β1)、Smad2/3和Smad4蛋白表达,抑制心肌纤维化,保护心脏。黄芪甲苷对异丙肾上腺素致心脏损伤、对血管紧张素Ⅱ致心脏损伤、对高血糖性心脏损伤都具有一定的保护作用。

AstragalosideⅣinhibits the apoptosis of hypoxic cardiomyocytes by inhibiting the nuclear factor-кB(NF-кB)pathway and reducing the expression level of NF-кB.Astragaloside IV regulates autophagic genes and up-regulates the Bcl-2 gene in B cell lymphoma/leukemia,the expression of Bcl-2 related X protein(Bax)and caspase-3 and the up-regulation of hypoxia inducible factor-1α(HIF-1α)have protective effects on ischemia-reperfusion heart.AstragalosideⅣcan also reduce the expression of myocardial transforming growth factorβ1α(TGF-β1α),Smad2/3,and Smad4 protein,inhibit myocardial fibrosis and protect the heart.AstragalosideⅣhas a certain protective effect on heart damage caused by isoproterenol,heart damage caused by angiotensinⅡ,and heart damage caused by hyperglycemia.