阿替卡因口腔科用药致药品不良反应文献分析

Literature Analysis of Adverse Drug Reactions Induced by Articaine as Stomatological Medicine

目的分析阿替卡因在口腔科应用致药品不良反应的特点及规律,为临床合理用药提供参考。方法以“阿替卡因”“碧兰麻”“致”“过敏”“不良反应”为检索词,检索中国知网及万方数据中2005年1月1日~2018年12月31日阿替卡因不良反应相关文献,按纳入与排除标准对文献资料进行统计和分析。结果共纳入27篇文献进行汇总分析,提取病例29例。药品不良反应累及全身性损害以及中枢及外周神经系统、心血管系统、呼吸系统等多个系统,用药后30 min内药品不良反应发生率较高。结论临床应重视阿替卡因在口腔科用药中发生的药品不良反应,对发生率较高的过敏反应应提高警惕,做好应对积极预防,减少药品不良反应对患者身体的损害。

Objective To analyze the characteristics and regularity of adverse reactions induced by articaine as a stomatological medicine so as to provide reference for the prevention of adverse reactions and rational clinical use.Methods Using“articaine”“primacaine”“to”“allergy”and“adverse reactions”as the key words,the articles in the CNKI and Wanfang detabase published from January 2005 to December 2018 were searched for and retrieved.The literature was analyzed according to the inclusion and exclusion criteria.Results A total of 27 papers(29 cases)were included.Systems and organs involved in ADRs were mostly central and peripheral nervous systems,the cardiovascular system and respiratory system.ADRs occurred most frequently within 30 min of medication.Conclusion More attention should be paid to articaine-caused adverse reactions in stomatology.Precautions should be taken to prevent adverse reactions,especially common allergic reactions so as to reduce the damage of adverse reactions to patients.