动态监测C-反应蛋白评估社区获得性肺炎病情严重程度的临床研究

Clinical Study of Dynamic Monitoring C-reactive Protein sed to Access the Severity of Community-acquired Pneumonia

目的探讨动态监测C-反应蛋白(CRP)评估社区获得性肺炎病情严重程度的临床价值。方法回顾性分析2018年1月~2019年12月于我院接受治疗的社区获得性肺炎患者467例,根据病情严重程度分为普通肺炎组(n=281)和重症肺炎组(n=186)。检测并比较两组治疗后1d、3d、7d血清CRP水平,分析CRP动态监测评估病情严重程度的价值。结果普通肺炎组治疗后1d、3d、7d血清CRP水平低于重症肺炎组(P<0.05);ROC曲线分析可知,治疗后7d血清CRP水平评估病情严重程度的AUC、敏感度、特异度均高于治疗后1d、3d血清CRP水平。结论CRP动态监测对社区获得性肺炎患者病情严重程度的评估价值较高,有利于临床判断病情严重程度,为临床后续治疗方案的制定提供了可靠的依据。

Objective:To explore the clinical value of dynamic monitoring C-reactive protein used to access the severity of communityacquired pneumonia.Methods:Totally,467 patients with community-acquired pneumonia were admitted and treated in our hospital from January 2018 to December 2019.Meanwhile,281 patients with pneumonia were divided into A group,and having 186 patients with severe pneumonia divided into B group.After treatment 1 day,3 days,7 days the levels of C-reactive protein were compared between the two groups for assessing the severity of pneumonia.Results:After treatment,ROC curve analysis showed that the AUC,the sensitivity and the specificity of C-reactive protein at 7 days were higher than those at 1day and 3 days.Conclusions:Dynamically monitoring C-reactive protein has distinct value to evaluate of community-acquired pneumonia,proving the reliable basis for follow-up treatment.