氯米芬联合罗格列酮对多囊卵巢综合征患者促排卵效果分析

Efficacy of Clomiphene Combined with Rosiglitazone on Ovulation for Treating Patients with Polycystic Ovary Syndrome

目的探讨氯米芬联合罗格列酮对多囊卵巢综合征(POCS)患者促排卵效果。方法选取2018年2月~2019年2月我院收治的多囊卵巢综合征患者70例,根据治疗方法的不同,均等分为研究组和基础组;基础组患者予氯米芬治疗,研究组患者予氯米芬联合罗格列酮治疗,观察两组治疗前后血清激素及INS水平变化,随访6个月后观察排卵率、妊娠率。结果治疗前两组FSH、T、LH、E2等激素水平和INS水平未见明显差异(P>0.05);治疗后:①T、LH等激素水平较治疗前均有明显下降,且研究组T、LH下降水平明显高于基础组,差异具有统计学意义(P<0.05);②两组E2、FSH水平均无明显变化(P>0.05);③研究组INS水平较治疗前明显下降,基础组无明显变化;研究组排卵率(82.86%)、妊娠率(45.71%),基础组(57.14%)、(25.71%),组间差异具有统计学意义(P<0.05)。结论氯米芬联合罗格列酮治疗能够明显改善多囊卵巢综合征激素水平,促进排卵率,提高妊娠率,值得在临床治疗中广泛推广。

Objective:To investigate the efficacy of clomiphene combined with rosiglitazone on ovulation for treating patients with polycystic ovary syndrome(POCS).Methods:Totally,70 patients with POCS were admitted and treated in our hospital from February 2018 to February 2019.They were divided into test group(n=35)and control group(n=35).Patients in control group were treated with clomiphene,while patients in test group were treated with clomiphene combined with rosiglitazone.The levels of serum hormone and INS were compared before and after treatment. After 6 months follow-up, the rate of ovulation and pregnancy were compared between the two groups. Results:(1) After treatment, the levels of T and LH were decreased, and the test group was superior to the control group (P < 0.05). (2) There was nosignificant difference in the levels of E2 and FSH in the two groups (P > 0.05). (3) The level of INS in test group was significantly decreased,however, there was no significant change in control group. (4) The rate of ovulation and pregnancy in test group were significantly higherthan those in control group (82.86% vs. 57.14%), (45.71% vs. 25.71%), respectively (P < 0.05).Conclusions: Clomiphene combined withrosiglitazone can improve the levels of serum hormone, promoting ovulation, and improving pregnancy rate on the patients with POCS.