N-6甲基腺嘌呤在乳腺癌发病机制及临床治疗中的研究进展

Research Progress of N6-methyladenosine in the Pathogenesis and Clinical Treatment of Breast Cancer

自DNA和组蛋白修饰的突破性发现以来,RNA修饰成为研究重点。在真核生物中,作为一种内表观遗传修饰,这种转录后RNA N6-甲基腺嘌呤(N6-methyladenosine,m6A)修饰是动态和可逆的。乳腺癌是最常见的女性恶性肿瘤,表现出显著的遗传、表观遗传和表型多样性。MRNA中的m6A可以控制肿瘤的自我更新和细胞命运,在乳腺癌发生发展中起着重要作用,是一种新的乳腺癌干预靶点。全文就m6A甲基化修饰在乳腺癌形成和发展中的分子机制,以及在乳腺癌临床治疗等方面的作用进行综述。

Since the discovery of DNA and histone modification,RNA modification has become a focus of research. In eukaryotes,as an internal epigenetic modification,post-transcriptional RNA N6-methyladenosine(m6A) modification is dynamic and reversible. Breast cancer is the most common cancer among female malignant tumors,showing significant genetic,epigenetic and phenotypic diversity. The m6A in m RNA can control the self-renewal and cell fate of tumors,and plays an important role in the occurrence and development of breast cancer. M6A is also a novel intervention target for breast cancer. This article reviews the molecular mechanism of m6A methylation modification in the formation and development of breast cancer,as well as the prospects for clinical treatment of breast cancer.