胸腔镜下肺癌根治术治疗早期非小细胞肺癌的效果及预后分析

Effect and prognosis of thoracoscopic radical resection of lung cancer in the treatment of early non-small cell lung cancer

目的探讨胸腔镜下肺癌根治术治疗早期非小细胞肺癌的效果及预后。方法本次研究对象为我院2013年3月至2016年3月收治的38例早期非小细胞肺癌患者,通过数字表法进行分组,各19例,对照组使用开胸肺癌根治术治疗,观察组使用胸腔镜下肺癌根治术治疗,比较2组患者的治疗效果及预后。结果观察组的术中出血量少于对照组,肠鸣音恢复时间、肛门排气时间、住院时间均短于对照组;术前,2组患者的各项肺功能指标差异无统计学意义,术后1个月,观察组的用力肺活量(FVC)、第1秒用力呼气量(FEV1)、FEV1与FVC的比值(FEV1/FVC)、6 min步行距离(6MWT),均高于对照组;术后3个月,观察组患者的并发症发生率低于对照组;术前,2组患者的生活质量(QOL)评分差异无统计学意义,术后6个月,观察组的评分高于对照组;观察组的近期疗效好于对照组,观察组的有效率(RR)、疾病控制率(DCR)均高于对照组,无疾病进展生存期(PFS)长于对照组;观察组的远期疗效好于对照组,术后3年观察组的生存率高于对照组。2组治疗后指标差异有统计学意义(P<0.05)。结论胸腔镜下肺癌根治术治疗早期非小细胞肺癌的效果及预后良好,可以有效改善患者的肺功能,降低并发症发生率,有利于患者尽快恢复,提高患者的生存质量及生存率,值得临床进一步推广使用。

Objective To investigate the effect and prognosis of radical thoracoscopic lung cancer in the treatment of early non-small cell lung cancer.Methods In this study,38 patients with early non-small-cell lung cancer were treated in our hospital from March 2013 to March 2016.Ninteen patients were grouped by digital table method.The control group was treated with radical thoracic lung cancer,and the observation group was treated with thoracoscopic lung cancer radical surgery,and the results and prognosis of the two groups were compared.Results The amount of bleeding in the observation group was less than that of the control group,the recovery time of intestinal sound,the time of anal exhaust and the stay time were shorter than that of the control group.Before operation,the functional index difference was not significant,and the FVC,FEV1,FEV1/FVC and 6MWT in the observation group were higher than that of the control group for 1 month after the operation,and the complication rate of the patients in the observation group was lower than that of the control group for 3 months after operation;the difference of the quality of life(QOL)of the two groups was not significant before operation,and 6 months after the operation,The efficacy of the observation group was higher than that of the control group.The effective rate(RR)and the disease control rate(DCR)of the observation group were higher than that of the control group,and the disease progression-free survival time(PFS)was longer than that of the control group,and the long-term effect of the observation group was better than that of the control group.Survival of the 3-year observation group after operation The rate was higher than that of the control group.There was a significant difference between the two groups after treatment(P<0.05).Conclusion The short-term curative effect,longterm effect and prognosis of patients with advanced non-small cell lung cancer treated with video-assisted thoraco-scopic resection of lung cancer can improve the lung function of patients,reduce the incidence of complications,be ben-eficial to the recovery of the patients as soon as possible,and improve the survival quality and survival rate of the patients.And is worthy of clinical popularization and use.