优化阿魏酸印迹微球的制备条件及其分子识别性能

Optimization Preparation and Molecular Recognition Performance of Ferulic Acid Imprinted Polymer Microspheres

以阿魏酸(FA)为模板分子、乙二醇二甲基丙烯酸酯(EDMA)为交联剂、丙烯酰胺(AM)为功能单体、偶氮二异丁腈(AIBN)为引发剂,制备的分子印迹聚合物微球对阿魏酸具有高选择性。通过优化制备条件获得阿魏酸分子印迹聚合物微球(MIPs),并对其结构、形貌及热稳定性进行表征。结果表明,模板分子为功能单体,交联剂的最佳比例为1∶4∶25,最佳的反应时间为24h,对肉桂酸的选择因子为0.201,说明此MIPs对阿魏酸具有良好的识别性能。

Ferulic acid imprinted polymer microspheres with highly selective have been prepared through a polymerization process,in which functional monomers acrylamide(AM)are copolymerized with crosslinkers ethylene glycol dimethacrylat(EDMA)in the existence of initiator azodiisobutyronitrile(AIBN).The structures,morphologies and thermal stability of imprinted polymer microspheres have been clearly studied.Especially,the reaction parameters have been optimized.The selective factor of imprinted polymer microspheres for cinnamic acid can reach 0.201 when the ratio of template molecule,functional monomers and crosslinkers is set as 1:4:25 at a reaction temperature of 24 h.It has been proved that this imprinted poly mer microspheres have good recognition performance for ferulic acid.