髓源性抑制细胞在肿瘤发生发展中的作用

Role of myeloid-derived suppressor cells in tumorigenesis and tumor development

髓源性抑制细胞(myeloid-derived suppressor cells,MDSCs)是一组异质细胞,在肿瘤相关免疫抑制中起关键作用。MDSCs通过免疫抑制作用,使肿瘤逃避免疫监控。肿瘤组织中MDSCs的浸润与患者预后不良及治疗的抵抗密切相关。MDSCs在转移中发挥重要作用,但MDSCs在远处器官建立转移前微环境的机制尚未明确。本文综述了MDSCs在肿瘤发生发展中的作用以及MDSCs参与转移前微环境形成的相关机制,并对MDSCs在肿瘤治疗中的潜在价值进行展望。

Myeloid-derived suppressor cells(MDSCs)are a heterogeneous group of cells that play a critical role in tumor-associated immune suppression.MDSCs allow tumors to evade immune surveillance through immunosuppressive effects.The infiltration of MDSCs into cancer tissues is associated with poor prognosis and resistance to therapies.MDSCs play an important role in metastasis,but the mechanism by which MDSCs establish the pre-metastatic microenvironment in distant organs is largely unknown.This article reviews the role of MDSCs in cancer development and progression and the related mechanisms through which MDSCs participate in the formation of the pre-metastatic niche.The potential therapeutic value of MDSCs in tumor development and progression was also investigated.