摘要
p38促分裂原活化的蛋白激酶(MAPK)信号通路是人体内最关键的细胞内信号通路之一,参与许多呼吸系统疾病的发生、发展。一方面,p38 MAPK信号通路可与糖皮质激素受体(GR)相互调节介导炎症相关反应;另一方面,p38 MAPK信号通路可影响GR对糖皮质激素的敏感性。与p38 MAPK信号通路相关的上下游因子及基因位点在哮喘、慢性阻塞性肺疾病、急性肺损伤、鼻窦炎-鼻息肉等常见呼吸系统疾病中不断被发现。因此,深入研究p38 MAPK信号通路对GR的调控机制,对未来研究新药、提高相关疾病临床疗效均具有重要意义。
The p38 mitogen-activated protein kinase(MAPK)signaling pathway is one of the most critical intracellular signaling pathways in the human body and is involved in the occurrence and development of many respiratory diseases.On one hand,p38 MAPK signaling pathway can interact with glucocorticoid receptor(GR)to mediate inflammation-related reactions;on the other hand,p38 MAPK signaling pathway affects GR′s sensitivity to glucocorticoid.In common respiratory diseases such as asthma,chronic obstructive pulmonary disease,acute lung injury,rhinosinusitis-nasal polyp,p38 MAPK signaling pathway related upstream and downstream factors and gene loci are constantly being discovered.Therefore,in-depth study of the regulatory mechanism of p38 MAPK signaling pathway on GR is of great significance for the future research on new drugs and improving the clinical efficacy of related diseases.
作者
吕天宜
李得民
程思益
杨道文
LYU Tianyi;LI Demin;CHENG Siyi;YANG Daowen(Department of Traditional Chinese Medicine for Pulmonary Diseases,Center of Respiratory Medicine,China-Japan Friendship Hospital/National Center for Respiratory Medicine/Institute of Respiratory Medicine,Chinese Academy of Medical Sciences/National Clinical Research Center for Respiratory Diseases/WHO Collaborating Centre for Tobacco Cessation and Respiratory Diseases Prevention,Beijing 100029,China)
出处
《医学综述》
2021年第4期625-630,共6页
Medical Recapitulate
基金
国家自然科学基金(81704045)。
