自噬在肾脏缺血再灌注损伤中的研究进展

Research Progress of Autophagy in Renal Ischemia Reperfusion Injury

肾脏缺血再灌注损伤是临床上急性肾损伤最常见的病因,防治困难。自噬作为一种细胞表现,是机体进化过程中的一种高度保守的代谢机制,广泛参与生物体代谢调节、生长发育、生命周期等。自噬在肾脏缺血再灌注损伤中可能起关键作用,并涉及多条信号通路,但自噬与肾脏缺血再灌注损伤复杂相互关系的确切机制还有待进一步阐明。因此,对肾小管细胞自噬的全面了解,可促进肾脏缺血再灌注损伤中新的药理调节因子的发现,为预防和治疗急性肾损伤提供新的方向。

Kidney ischemia reperfusion injury is the most common cause of acute kidney injury in clinical,and it is difficult to prevent and treat.Autophagy,as a cellular activity,is a highly conservative metabolic mechanism during the evolution of the organism.It is widely involved in the metabolic regulation,growth and development,and life cycle of the organism.Autophagy may play a key role in renal ischemia-reperfusion injury and involve multiple signaling pathways,but the precise mechanism behind the complex relationship between autophagy and renal ischemia-reperfusion injury needs to be further elucidated.Therefore,a comprehensive understanding of renal tubular autophagy will promote the discovery of new pharmacological regulatory factors in renal ischemia-reperfusion injury,and provide a new direction for the prevention and treatment of acute kidney injury.