动脉粥样硬化患者炎症因子标志物的研究进展

Research Progress in Markers of Inflammatory Factors in Patients with Atherosclerosis

炎症因子(包括促炎因子和抑炎因子)均参与动脉粥样硬化(As)的发生发展。白细胞介素(IL)-6、C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)等促炎因子通过破坏血管内皮、激活黏附因子、增加脂质沉积等途径诱导As的发生或参与As的进展,可为As的诊断与病情评估提供依据。IL-10、脂联素等是目前发现的可能参与As发生发展的抑炎因子,这些抑炎因子在辅助As诊断的同时,也为As的治疗提供了新靶点。为提升As诊断的准确度与治疗效果,未来应进一步研究As炎症因子标志物,从而为As的早期检出及治疗提供新途径。

Inflammatory factors(including pro-inflammatory factors and anti-inflammatory factors)are involved in the occurrence and development of atherosclerosis(As).Interleukin(IL)-6,C-reactive protein(CRP),tumor necrosis factor-α(TNF-α),etc.all induce the occurrence of As or participate in the progression of As by destroying vascular endothelium,activating adhesion factors,and increasing lipid deposition,which can provide a basis for the diagnosis and evaluation of As.IL-10,adiponectin,etc.are currently discovered anti-inflammatory factors that may participate in the occurrence and development of As.While these anti-inflammatory factors assist the diagnosis of As,they also provide new targets for the treatment of As.In order to improve the accuracy of the diagnosis and therapeutic effect of As,we should further study the inflammatory markers of As in the future,so as to find new ways for the early detection and treatment.